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Mubychem Group, is a mature manufacturing company since generations. Engaged in manufacture and supply of Pharmaceutical Intermediates and Excipients, Oil field & fracturing chemicals, Specialty tailor made grades of chemicals in India. With several manufacturing facilities in India and world wide contacts and toll manufacturers we are exporting to all the countries in the world.. |
The company and associated units have certificates & accreditations like FDA - GMP approval; ISO-9001 Certified; "REACH" Registered; ISO-22000; Kosher Certified; Halal Certified; HACCP. We offer Commercial Pure & Pharmacopoeia IP BP USP FCC Food Grade ACS AR Analytical Reagent Grades of Chemicals |
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Citric Acid BP Citric Acid USP Citric Acid Manufacturers
For MSDS Sheet Click MSDS of Citric Acid Monohydrate BP USP IP FCC Food grade Manufacturers
Citric Acid Monohydrate BP
C6H8O7-H2O -- 210 -- 5949-29-1
Citric Acid BP Monohydrate
DEFINITION
2-Hydroxypropane-1,2,3-tricarboxylic acid monohydrate.
Content
99.5 per cent to 100.5 per cent
(anhydrous substance).
CHARACTERS
Appearance
White or almost white, crystalline
powder, colourless crystals or granules, efflorescent.
Solubility
Very soluble in water, freely
soluble in ethanol (96 per cent).
IDENTIFICATION
First identification B,
E.
Second identification A,
C, D, E.
A. Dissolve 1 g in 10 ml of water. The solution is strongly acidic.
B. Infrared absorption
spectrophotometry.
C. Add about 5 mg to a mixture of
1 ml of acetic anhydride and 3 ml of pyridine. A red colour
develops.
D. Dissolve 0.5 g in 5 ml of water, neutralize using 1 M sodium hydroxide
(about 7 ml), add 10 ml
of calcium chloride solution R and heat to boiling. A white precipitate
is formed.
E. Water (see Tests).
TESTS
Appearance of solution
The solution is clear and
not more intensely coloured than reference.
Dissolve 2.0 g in water and
dilute to 10 ml with the same solvent.
Readily carbonizable substances
To 1.0 g in a cleaned test tube
add 10 ml of sulphuric acid and immediately heat the mixture in a
water-bath at 90 ± 1 °C for 60 min. Cool rapidly immediately afterwards. The
solution is not more intensely coloured than a mixture of 1 ml of red primary
solution and 9 ml of yellow primary solution.
Oxalic acid
Maximum 360 ppm, calculated as
anhydrous oxalic acid.
Sulphates
Maximum 150 ppm.
Aluminium
Maximum 0.2 ppm, if intended for
use in the manufacture of dialysis solutions.
Heavy metals
Maximum 10 ppm.
Water
7.5 per cent to 9.0 per cent,
determined on 0.500 g.
Sulphated ash
Maximum 0.1 per cent, determined
on 1.0 g.
Bacterial endotoxins
Less than 0.5 IU/mg, if intended
for use in the manufacture of parenteral dosage forms without a further
appropriate procedure for the removal of bacterial endotoxins.
Citric Acid Monohydrate USP
Citric Acid USP Monohydrate
C6H8O7·H2O 210.14
1,2,3-Propanetricarboxylic acid,
2-hydroxy-, monohydrate.
Citric Acid Monohydrate contains one molecule of water of hydration. It contains not less than 99.5 percent and not more than 100.5 percent of C6H8O7, calculated on the anhydrous basis.
Labeling— Where it is
intended for use in dialysis solutions, it is so labeled. Where Citric Acid
Monohydrate must be subjected to further processing during the preparation of
injectable dosage forms to ensure acceptable levels of bacterial endotoxins, it
is so labeled. Where Citric Acid Monohydrate is sterile, it is so labeled.
Identification, Infrared
Absorption 197K— Dry the substance to be examined at 105 for 2
hours.
Bacterial endotoxins— The level of bacterial endotoxins is such that the requirement in the
relevant dosage form monograph (s) in which Citric Acid Monohydrate is used can
be met.
Sterility— Where
the label states that Citric Acid Monohydrate is sterile, it meets the
requirements for Sterility, in the relevant dosage form monograph (s) in
which Citric Acid Monohydrate is used.
Water: between 7.5% and
9.0%.
Residue on ignition: not
more than 0.1%, determined on 1.0 g.
Readily carbonizable
substances— To pass the test
Sulfate— 0.015%.
Heavy metals: 0.001%.
Limit of oxalic acid— 0.036%.
Citric Acid FCC
C6H8O7 Formula wt, anhydrous
192.13
C6H8O7·H2O Formula wt, monohydrate
210.14
INS: 330 CAS: anhydrous [77-92-9]
CAS: monohydrate [5949-29-1]
DESCRIPTION
Citric Acid occurs as colorless,
translucent crystals or as a white, granular to fine, crystalline powder. It is
anhydrous or contains one molecule of water of hydration. The hydrous form is
efflorescent in dry air. It is odorless and has a strongly acid taste. One gram
is soluble in about 0.5 mL of water, in about 2 mL of alcohol, and in about 30
mL of ether.
Function: Sequestrant;
dispersing agent; acidifier; flavoring agent.
REQUIREMENTS
Labeling: Indicate whether
it is anhydrous or hydrous.
Identification: A 1:10
aqueous solution gives positive tests for Citrate.
Assay: Not less than 99.5%
and not more than 100.5% of C6H8O7, calculated on the anhydrous basis.
Lead: Not more than 0.5
mg/kg.
Oxalate: Passes test.
Readily Carbonizable: Substances
Passes test.
Residue on Ignition: Not
more than 0.05%.
Tridodecylamine
(for
solvent-extracted Citric Acid only)
Not more than 0.1 mg/kg.
Water: Anhydrous: Not
more than 0.5%; Monohydrate: Not more than 8.8%.
Citric Acid ACS
Citric Acid, Anhydrous, and Citric Acid, Monohydrate
2-Hydroxy-1,2,3-propanetricarboxylic Acid
HOCOCH2C(OH)(COOH)CH2COOH; Formula
Wt. 192.13
HOCOCH2C(OH)(COOH)CH2COOH
.
H2O;
Formula Wt. 210.14
CAS Number
77-92-9 (Anhydrous); 5949-29-1 (Monohydrate)
REQUIREMENTS
Assay:
99.5% C6H8O7 99.0-102.0% C6H8O7. H2O
min
MAXIMUM ALLOWABLE
Insoluble matter:
0.005%
Residue after ignition:
0.02%
Chloride (Cl): 0.001%
Oxalate (C2O4): Passes test
Phosphate (PO4): 0.001%
Sulfate (SO4): 0.002%
Iron (Fe): 3 ppm
Lead (Pb): 2 ppm
Substances carbonizable
by hot sulfuric acid: Passes test
Citric Acid Manufacturers:
MUBY CHEMICALS GROUP
DONGRI-CHINCHBUNDER, MUMBAI 400009, INDIA
TEL: (OFFICE)
91-22-23770100, 91-22-23726950, 91-22-23774610, 23723564.
e-mail: info@mubychem.com
